synergism and antagonism in pharmacology

Cancer Chemother Pharmacol. Please check your email for instructions on resetting your password. 2019 Mar 22;82(3):469-484. doi: 10.1021/acs.jnatprod.9b00176. Jensen PB, Holm B, Sorensen M, Christensen IJ, Sehested M. Br J Cancer. In one particular case the null equation leads to conclusions which are very similar to those reached by an earlier author who did not use the null method. Indirectly acting agonists. Get the latest public health information from CDC: https://www.coronavirus.gov. This review discusses recent findings on antimalarial drug interactions and some pitfalls in their analysis and interpretation.

doi: 10.1371/journal.pone.0235723. Suberoylanilide hydroxamic acid overcomes erlotinib-acquired resistance via phosphatase and tensin homolog deleted on chromosome 10-mediated apoptosis in non-small cell lung cancer. Print 2020 Mar 24. In vitro cross-resistance and collateral sensitivity in seven resistant small-cell lung cancer cell lines: preclinical identification of suitable drug partners to taxotere, taxol, topotecan and gemcitabin. Use the link below to share a full-text version of this article with your friends and colleagues. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, © 2020 The British Pharmacological Society, I have read and accept the Wiley Online Library Terms and Conditions of Use. 2005 Aug 15;41 Suppl 4:S247-57. Background: Learn more. Chin Med J (Engl). eCollection 2020. 2020 Jun 1;15(6):e0234070. Clipboard, Search History, and several other advanced features are temporarily unavailable. eCollection 2020. Luszczki JJ, Panasiuk A, Zagaja M, Karwan S, Bojar H, Plewa Z, Florek-Łuszczki M. PLoS One. and you may need to create a new Wiley Online Library account. Epub 2007 Sep 17. NLM Learn about our remote access options, Department of Pharmacology, The School of Medicine, The Worsley Medical and Dental Building, University of Leeds, Leeds LS29JT. Treatment of relapsed aggressive lymphomas: regimens with and without high-dose therapy and stem cell rescue. In vitro sensitivity of human endometrial cancer cell lines to paclitaxel or irinotecan (CPT-11) in combination with other aniticancer drugs. doi: 10.1371/journal.pone.0234070. Conclusions and implications: 2002 May;49 Suppl 1:S13-20. 1995 Jun;22(3 Suppl 6):12-5. Dose-response curves and mechanisms of drug action, https://doi.org/10.1111/j.1476-5381.1981.tb16781.x. 2019 Apr;9:93-99. doi: 10.1016/j.ijpddr.2019.02.004. A fundamental temperature-dependent difference between β-adrenoceptor agonists and antagonists. USA.gov. Get the latest research from NIH: https://www.nih.gov/coronavirus.  |  Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil. Furthermore, making mechanistic deductions from drug-interaction data is not straightforward and of the many reported instances of antimalarial synergism or antagonism, few have been fully explained biochemically. Epub 2019 Feb 22. 15 1994 Oct 19;86(20):1493-5. doi: 10.1093/jnci/86.20.1493. Epub 2019 Mar 7. van Schalkwyk DA, Blasco B, Davina Nuñez R, Liew JWK, Amir A, Lau YL, Leroy D, Moon RW, Sutherland CJ.

However, the null equations give a clearer insight into the quantitative aspects of functional interaction. Antimalarial drugs: modes of action and mechanisms of parasite resistance. The combination of paclitaxel and cisplatin was synergistic against 833K/64CP10 cells and moderately antagonistic against 833K cells.

Application of the operational model of agonism to establish conditions when functional antagonism may be used to estimate agonist dissociation constants. Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines. The present quantitative data analyses for synergism or antagonism provide a basis for a rational design of clinical protocols for combination chemotherapy in patients with advanced germ cell tumors. Role of modelling in joint action studies. Oxid Med Cell Longev. On the other hand, it may be possible to use the null equations, or similar principles, to test the validity of postulated mechanisms and sites of action of functional interactants. NIH

Opportunities and Limitations for Untargeted Mass Spectrometry Metabolomics to Identify Biologically Active Constituents in Complex Natural Product Mixtures. This site needs JavaScript to work properly. 1997;75(6):869-77. doi: 10.1038/bjc.1997.154. The degrees of antagonism were as follows: cisplatin + etoposide > or = paclitaxel + vincristine > paclitaxel + cisplatin + vincristine > cisplastin + vincristine. In Vitro Performance and Analysis of Combination Anti-infective Evaluations. Estimation of Agonist Activity at G Protein-Coupled Receptors: Analysis of M

Alejandro Diaz-Toledo, Aron Jurkiewicz, Dissociation constants and relative efficacies estimated from the functional antagonism of β-adrenoceptor agonists on transmural stimulation in rat vas deferens, European Journal of Pharmacology, 10.1016/0014-2999(90)94143-L, 191, 2, (157-165), (1990). Int J Parasitol Drugs Drug Resist. These agents were used singly or in two- and three-drug combinations and were selected because they represent five distinct categories of antineoplastic mechanisms.

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